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Aspirin INN: acetylsalicylic acid
Clinical data
Pronunciationacetylsalicylic acid / ə ˌ s iː t əl ˌ s æ l ɪ ˈ s ɪ l ɪ k /
Trade namesBayer Aspirin, many others
License dataEU  EMA:  by INN, US   FDA: Aspirin
Pregnancy categoryAU: C US: C (Risk not ruled out) D in the 3rd trimester
Routes of administrationby mouth, rectal, lysine acetylsalicylate may be given intravenously or intramuscularly
ATC codeA01AD05 ( WHO ) B01AC06 ( WHO ), N02BA01 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) except when given intravenously (in which case it is schedule 4), used in animal medicine (schedule 5/6) or when the dose is higher than usual., UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailability80–100% [2]
Protein binding80–90% [1]
MetabolismLiver, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall. [1]
Elimination half-lifeDose-dependent; 2 h to 3 h for low doses (100 mg or less), 15 h to 30 h for large doses. [1]
ExcretionUrine (80–100%), sweat, saliva, feces [2]

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