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Clinical data
Pronunciation/ ˌ d aɪ f ɛ n ˈ h aɪ d r ə m iː n /
Trade namesBenadryl, Unisom, Sominex, others
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Dependence liabilityVery low
Routes of administrationBy mouth, intramuscular injection, intravenous, topical, rectal
ATC codeD04AA32 ( WHO ) D04AA33 ( WHO ), R06AA02 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) US: OTC
Pharmacokinetic data
Bioavailability40–60% [2]
Protein binding98–99%
MetabolismLiver (CYP2D6 (80%), CYP3A4 (10%)) [1]
Elimination half-lifeRange: 2.4–13.5 hrs [3] [2] [4]
ExcretionUrine: 94% [5] Feces: 6% [5]

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Benadryl product names pills:
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Benadryl info
Pill name Benadryl
Benadryl all synonymsadryl, air salonpas, aliserin, allerdryl, allergan, allergina, allerjin, allernix, antomin, apap noc, arcodryl, asdrin, azaron, benaderma, benalet, benison, benocten, benylan, benylin, betadorm, betadrin, betasleep, brudifen, butix, caladryl, calmaben, cerylana, codilergi, coldistan, dermodrin, desentol, despa, di-fedril, dibondrin, didryl, difedrin, difenhidramina, difin, dimedrol, dimedrolum, dimedrolum-darnitsa, dimidril, diphamine, diphenhist, diphenhydramin, diphénhydramine, diphenhydraminum, diyenil, dolestan, dorenta, dormital, drafen, dramalyn, drogryl, emesan, expectalin, exylin, fabolergic, fenotral, genahist, hemodorm, hevert-dorm, hiship s, histaler, histam, histaxin, histergan, histodor, indumir, klonadryl, miles, moradorm, nardyl, nautamine, neosayomol, nervo opt, nighlus, noctor, northicalm, nuicalm, nustasium, nyflu, nytol, otede, paxidorm, pedeamin, pediacare, pedilar, pedilin, pediphen, pektolin, phenadryl, pretniezes, psilo, r calm, reasec, recodryl, rescalmin, resmin, restamin, rhinitin, rhinocap retard, salymetick, scandin, sediat, sedopretten, sleepinal, snuzaid, somnium, somol, soñodor, stopko
Active substancesdiphenhydramine
Best price 166 USD
Bestellers 60 amount of packaging x 25 mg
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    Large local reactions develop slowly and usually require a trip to the family doctor, not the ER. You can't predict if you'll get a large local reaction, but, "If you've had this reaction before, you are more likely to have it again, says Kelkar.It other words, it will try to find an explanation and an appropriate response, fast.

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