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Talk to your doctor if you are using marijuana (cannabis) Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) Liquid products, chewable tablets, or dissolving tablets/strips may contain sugar and/or aspartame. Liquid products may also contain alcohol. Benadryl (diphenhydramine) package 25 mg 60 the amount of packaging.

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Diphenhydramine
Clinical data
Pronunciation/ ˌ d aɪ f ɛ n ˈ h aɪ d r ə m iː n /
Trade namesBenadryl, Unisom, Sominex, others
AHFS/Drugs.comMonograph
MedlinePlusa682539
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Dependence liabilityVery low
Routes of administrationBy mouth, intramuscular injection, intravenous, topical, rectal
ATC codeD04AA32 ( WHO ) D04AA33 ( WHO ), R06AA02 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) US: OTC
Pharmacokinetic data
Bioavailability40–60% [2]
Protein binding98–99%
MetabolismLiver (CYP2D6 (80%), CYP3A4 (10%)) [1]
Elimination half-lifeRange: 2.4–13.5 hrs [3] [2] [4]
ExcretionUrine: 94% [5] Feces: 6% [5]

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Active substancesdiphenhydramine
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Serious symptoms such as trouble breathing or swallowing occur.Often clients report that they can only sleep if they watch television in bed or read in bed, yet upon further assessment they reluctantly admit that these activities often perpetuate staying awake.

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