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Pediatric Irritable Bowel Syndrome Medication: Antispasmodic and Lubiprostone, a locally mebeverine 135mg used for chloride channel agonist, has been approved in the United States for the treatment of CIC in adults and for irritable bowel syndrome with predominant constipation in women at least 18 years old.In Germany, they haven't been approved for the treatment of IBS, so they can only be used off-label.

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Effects in repeat-dose toxicity studies, after oral and parenteral doses, were mebeverine 135mg used for of central nervous involvement with behavioural excitation, mainly tremor and convulsions. In the dog, the most sensitive species, these effects were seen at oral doses equivalent to 3 times the maximum recommended clinical dose of 400mg/day based on body surface area mg/m2 comparisons.You can also mention any other factors that might explain the symptoms such as stress at work You may gradually start recognizing patterns that help you identify which foods you don't tolerate.

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No posology studies in elderly, renal and/or hepatic impaired patients have been performed. No specific risk for elderly, renal and/or hepatic impaired patients could be identified from available post-marketing data.There are no or limited amounts of data from the use of mebeverine in pregnant women.

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