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Developed in the 1980s. Examples include aripiprazole (Abilify®) and risperidone (Risperdal®). Atypical antipsychotics became more popular.

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Clinical data
Pronunciation/ ˌ eɪ r ɪ ˈ p ɪ p r ə z oʊ l / AIR -i- PIP -rə-zohl Abilify / ə ˈ b ɪ l ɪ f aɪ / ə- BIL -i-fy
Trade namesAbilify, others
License dataEU  EMA:  by INN, US   FDA: Aripiprazole
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth (tablets, dissolving tablets, solution); IM (including a depot)
ATC codeN05AX12 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability87% [1] [2] [3]
Protein binding>99% [1] [2] [3]
MetabolismLiver (mostly via CYP3A4 and 2D6 [1] [2] [3] )
Elimination half-life75 hours (active metabolite is 94 hours) [1] [2] [3]
ExcretionRenal (27%; <1% unchanged), Faecal (60%; 18% unchanged) [1] [2] [3]

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Aripiprazole properties
Drugs name Aripiprazole
Aripiprazole product nameabilitat, aripiprazola, aripiprazolum
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