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Sleeping at an altitude higher than you're accustomed to may increase your risk of sleep apnea. Honduras: Investigate Murder of Transgender Activist - Refworld Patients with risk factors for impaired clearance: In theos 24 theophylline 12-15 years of age, the final theophylline dose should not exceed 16 mg/kg/day up to a maximum of 400 mg/day.

In adolescents Children 12 - 15 years 45 kg without risk factors for impaired clearance As with all theophylline products, doses greater than 600 mg should be titrated according to theo 24 theophylline level For most patients, steady state will be reached after 3 days see pharmacokinetics below so lab monitoring should occur at 3 day intervals during dose adjustments After an appropriate maintenance dose is determined, serum theophylline concentrations should be monitored at 6 month intervals for rapidly growing children and Peak levels Extended-release tablet 12 hours after an evening theo 24 theophylline or 9 hours after a morning dose at steady state Dose adjustment recommendations for serum theophylline levels are presented in the table below If symptoms are not controlled and current dosage is tolerated, increase dose about 25% Recheck serum If symptoms are controlled and current dosage is tolerated, maintain dose and recheck serumconcentration at 6-12 month intervals.

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Clinical data
Trade namesTheolair, Slo-Bid
Pregnancy categoryAU: A [ citation needed ] US: C (Risk not ruled out)
Routes of administrationBy mouth, IV, rectal
ATC codeR03DA04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: P (Pharmacy medicines) US: ℞-only
Pharmacokinetic data
Bioavailability100% (IV)
Protein binding40% (primarily to albumin)
MetabolismHepatic to 1-methyluric acid
Elimination half-life5–8 hours

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