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TIMOPTIC-XE timolol maleate ophthalmic gel forming solution 0.Beta-adrenergic receptor blockade reduces cardiac output in both healthy subjects and patients with heart disease. In patients with severe impairment of myocardial function beta-adrenergic receptor inhibitors may inhibit the stimulatory effect of the sympathetic nervous system necessary to maintain adequate cardiac function.
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2.Timolol ophthalmic solution also is contraindicated in patients with known hypersensitivity to the drug or any ingredient in the formulation.
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