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Effects on haematology parameters were found in each species, including dose-related reductions in circulating leukocytes in seroquel labs to monitor and non-specific reductions of circulating leukocytes in rats; however, no evidence of bone marrow cytotoxicity was found. Reversible neutropenia, thrombocytopenia, or anaemia developed in a few dogs treated with 8 or 10 mg/kg/day total olanzapine exposureAUCis 12- to 15-fold greater than that of a man given a 12-mg dose In cytopenic dogs, there were no adverse effects on progenitor and proliferating cells in the bone marrow.J Psychiatry Neurosci.
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Some clinicians state that olanzapine dosages of up to 30 mg daily may produce further clinical improvement in schizophrenia patients who did not respond adequately to dosages of up to 20 mg daily; however, they recommend that caution be exercised when dosage of the drug exceeds 40 mg daily because of the potential for serious adverse effects e.
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