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Fluoxetine
Fluoxetine (top), ( R )-fluoxetine (center), ( S )-fluoxetine (bottom)
Clinical data
Pronunciation/ f l u ˈ ɒ k s ə t iː n /
Trade namesProzac, Sarafem, Adofen, other
AHFS/Drugs.comMonograph
MedlinePlusa689006
License dataUS   FDA: Fluoxetine
Pregnancy categoryAU: C US: C (Risk not ruled out)
Dependence liabilityPhysical: Low Psychological: Low
Addiction liabilityNone
Routes of administrationBy mouth
Drug classSelective serotonin reuptake inhibitor (SSRI) [1]
ATC codeN06AB03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability60–80% [1]
Protein binding94–95% [3]
MetabolismLiver (mostly CYP2D6-mediated) [2]
Metabolitesnorfluxotine, desmethylfluoxetine
Elimination half-life1–3 days (acute) 4–6 days (chronic) [2] [4]
ExcretionUrine (80%), faeces (15%) [2] [4]

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